PROFILE
个人简介
主要开展胃肠道肿瘤免疫微环境与自身免疫性肝病发病机制相关研究工作。
已发表 SCI 论文 22 篇，其中以第一/通讯作者在 Advanced Science、Journal of Pathology、Science Advances、Cell Communication and Signaling 等国际高水平期刊发表 SCI 论文 9 篇，累计被引用 830 余次。
RESEARCH
研究方向
- 胃肠道肿瘤免疫微环境与自身免疫性肝病发病机制
擅长实验技术
- R、Python 及 Shell 编程语言，生物大数据分析与可视化
- 单细胞测序与空间转录组测序数据分析
- 流式细胞术
- 小鼠肿瘤模型构建等免疫学实验方法
GRANTS & SERVICE
主持项目与学术服务
主持项目
- 国家自然科学基金面上项目
- 国家自然科学基金青年项目
- 中国博士后面上项目
SELECTED PAPERS
代表性论文
- PD-1+CD8+ T Cell-Mediated Hepatocyte Pyroptosis Promotes Progression of Murine Autoimmune Liver DiseaseJie Long†, Si-Yu Yang†, Zhen-Hua Bian, Hao-Xian Zhu, Min Ma, Xiao-Qing Wang, Liang Li, Weici Zhang, Ying Han*, M. Eric Gershwin*, Zhe-Xiong Lian* and Zhi-Bin Zhao*
- Spontaneous development of an autoimmune hepatitis – primary biliary cholangitis overlap syndrome in dnTGFβRII Aire-/- miceJie Long†, Si-Yu Yang†, Meng-Xing Huang, Pan-Yue Luo, Liang Li, Koichi Tsuneyama, Aftab A Ansari, Ling Lu*, M Eric Gershwin*, Zhe-Xiong Lian* and Zhi-Bin Zhao*
- Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancerFei Wang†, Jie Long†, Liang Li, Zi-Xin Wu, Tian-Tian Da, Xiao-Qing Wang, Chuan Huang, Yi-Hua Jiang, Xue-Qing Yao, Hai-Qing Ma*, Zhe-Xiong Lian*, Zhi-Bin Zhao*, Jie Cao*
- Bone marrow CD8+ Trm cells induced by IL-15 and CD16+ monocytes contribute to HSPC destruction in human severe aplastic anemiaJie Long†, Xing You†, Qiong Yang†, Song-Rong Wang, Ming Zhou, Wei Zhou, Cai-Xia Wang, Hua-Feng Xie, Yu-Ping Zhang, Shun-Qing Wang*, Zhe-Xiong Lian*, Liang Li*
- Mesentery morphological features on computed tomography for preoperative prediction of tumor invasion and lymph node metastasis in colon cancerFei Wang, Chuan Huang, Hai-Qing Ma, Xue-Qing Yao, Jun-Jiang Wang*, Jie Long*
- CD69+CD103+CD8+ tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancerZi-Xin Wu†, Tian-Tian Da†, Chuan Huang, Xiao-Qing Wang, Liang Li, Zhi-Bin Zhao, Ting-Ting Yin, Hai-Qing Ma, Zhe-Xiong Lian, Jie Long*, Fei Wang* and Jie Cao*
- Characterization of Organ-Specific Regulatory B Cells Using Single-Cell RNA SequencingSi-Yu Yang†, Jie Long†, Meng-Xing Huang, Pan-Yue Luo, Zhen-Hua Bian, Ya-Fei Xu, Cheng-Bo Wang, Shu-Han Yang, Liang Li, Carlo Selmi, M. Eric Gershwin, Zhi-Bin Zhao* and Zhe-Xiong Lian*
- Autophagy of Kupffer cells modulates CD8+ T cell activation in primary biliary cholangitisPan-Yue Luo†, Min Ma†, Meng-Chu Liu†, Ye-Hui Wu, Jie Long, Meng-Xing Huang, Si-Yu Yang, Tian-Tian Da, Koichi Tsuneyama, Qiao Li, Haosheng Jin, Zhi-Bin Zhao, Jun Wang, Xiong Ma, Merrill Eric Gershwin, Ying Han*, Zhe-Xiong Lian* and Liang Li*