RESEARCH
研究方向
- 肝脏代谢性疾病免疫代谢相关研究
擅长实验技术
- 小鼠模型的构建（包括肝癌、高脂、酒精肝、纤维化和肝再生等）
- 蛋白质组学/代谢组学（Thermo QE Plus）和靶向代谢（SCIEX 4500）检测和分析
- 10x Visium 空间转录组建库和 R 语言分析
SELECTED PAPERS
代表性论文
- Targeting OXCT1-mediated ketone metabolism reprograms macrophages to promote antitumor immunity via CD8+ T cells in hepatocellular carcinomaZhu Chuxu#, Yan Kai#, Chen Liang, Huang Rongrong, Bian Zhenhua, Wei Haoran, Gu Xuemei, Zhao Yangyang, Liu Mengchu, Suo Caixia, Li Zhikun, Yang Zhiyi, Lu Minqiang, Hua Xuefeng, Li Liang, Zhao Zhibin, Sun Linchong, Zhang Huafeng, Gao Ping*, Lian Zhexiong*
- Spatial transcriptomics reveals prognosis-associated cellular heterogeneity in the papillary thyroid carcinoma microenvironmentYan Kai#, Liu Qingzhi#, Huang Rongrong#, Jiang Yihua, Bian Zhenhua, Li Sijin, Li Liang, Shen Fei, Tsuneyama Koichi, Zhang Qingling*, Lian Zhexiong, Guan Haixia*, Xu Bo*
- Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogrammingYan Kai, Da Tiantian, Bian Zhenhua, He Yi, Liu Mengchu, Liu Qingzhi, Long Jie, Li Liang, Gao Caiyue, Yang Shuhan, Zhao Zhibin* and Lian Zhexiong*